Matthew A. Movsesian, M.D.
Professor of Internal Medicine and Pharmacology and Chief, Cardiology, VA Salt lake City Health Care System
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| Contact |
Patient Appts:(801) 585-7676
Administrative: (801) 585-3362 Fax: (801) 581-7735
 Email Dr. Movsesian
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| Office |
Division of Cardiology
University of Utah School of Medicine, Room 4B121
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| Education |
Medical School:
Harvard University
Residency:
National Heart, Lung & Blood Institute
Fellowship:
University of California, San Francisco
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| Faculty Positions: |
University of Utah, 1986
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| Clinical Specialty: |
Cardiology
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| Research Interests: |
My research focuses on cAMP- and cGMP-mediated intracellular signalling in cardiac and vascular smooth muscle myocytes. Particular interests are the phosphodiesterases that hydrolyse cAMP and cGMP and the phosphatases that dephosphorylate proteins phosphorylated by cAMP- and cGMP-dependent protein kinases. In collaboration with investigators at NIH, we have cloned and characterised PDE3 isoforms in cardiac and vascular smooth muscle, and we are now working on discovering the mechanism by which these isoforms are regulated and targeted to specific intracellular locations. Meanwhile we have identified several important phosphatase isoforms in cardiac and vascular myocytes, and we are engaged in determining the mechanisms by which subunit interactions modulate function and in discovering ways to disrupt these interactions. Ultimately our experiments may lead to the discovery of new therapeutic agents for the treatment of heart failure.
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| SELECTED PUBLICATIONS:
| Krall J, Taskèn K, Staheli J, Jahnsen T and Movsesian MA. 1999. Identification and quantitation of cAMP-dependent protein kinase R subunit isoforms in subcellular fractions of human myocardium. J Mol Cell Cardiol 31:971-980.
Movsesian MA. 1999. Beta-adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors: shifting the focus from inotropy to cyclic adenosine monophosphate. J Am Coll Cardiol 34:319-324.
Lutz S, Mura R, Baltus D, Movsesian MA, Kbler W and Niroomand F. 2001. Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium. Cardiovasc Res 49:48-55.
Choi Y-H, Ekholm D, Krall J, Ahmad F, Degerman E, Manganiello VC and Movsesian MA. 2001. Identification of a novel isoform of the cyclic nucleotide phosphodiesterase PDE3A expressed in vascular smooth muscle myocytes. Biochem J 353:41-50.
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