Research

Advances in vascular care can only occur by exploring the unknown. Members of the Division of Vascular Surgery are actively researching a variety of questions ranging from why blood vessels develop vascular disease in the first place to the best ways to treat established disease in order to achieve the best outcome.

Clinical Trials now enrolling  

Research Projects Listed by M.D.

• Larry Kraiss, M.D.
• Mark Sarfati, M.D.
• Michelle Mueller, M.D.
• Daniel Kinikini, M.D.

Larry Kraiss, M.D.

Project Title: 11931-02 Injection of Autologous CD34-Positive Cells for Improved Symptomatic Relief and Ischemic Wound Healing in Subjects with Moderate or High-Risk Critical Limb Ischemia.

• Co-Investigators: Mark Sarfati, Michelle Mueller, Daniel Kinikini

Funding Source: Baxter BioSurgery     Sponsor: Douglas W. Losordo, MD, Northwestern University  

• Project Date: 4/2008-Present

Project Title:  CVT-0827 Study to Determine the Resource Use, Costs, and Health Related Quality of Life among Patients with Venous Leg Ulcers

• Co-Investigators: Mark Sarfati, Michelle Mueller, Daniel Kinikini
• Funding Source: Hoffmann-LaRoche/ Covance Inc.
• Project Date: 3/2007-4/2008

Project Title: Peripheral Arterial Disease (PAD) Fontaine Stage II

• Co-Investigators: Mark Sarfati, Michelle Mueller, Daniel Kinikini
• Funding Source: Sanofi Aventis  
• Project Date: 11/2006-Present

Project Title: NC19453 Phase II, Double-blind, randomized, placebo-controlled parallel group study, evaluating the efficacy and safety of three doses of study drug, RO4607381, over a 24 week period in high risk patients with below average HDL-C levels. (Local Principal Investigator (PI))

• Co-Investigators: Mark Sarfati, Michelle Mueller, Daniel Kinikini
• Funding Source: Hoffmann-LaRoche/ Covance Inc.
• Project Date: 7/2006-4/2008

Project Title: NAPA-2: Study to Evaluate the Efficacy and Safety of Alfimeprase in Subjects with Acute Peripheral Arterial Occlusion (Local Co- Investigator (Co-I))

• Co-Investigators: Mark Sarfati, Michelle Mueller
• Funding Source: Nuvelo, Inc.
• Project Date: 10/2005-12/2006

Project Title: Translational Control of Rapid Endothelial Responses. (PI)

• Funding Source: 1 NIH RO1 HL075507
• Project Date: 1/1/2004 -12/31/2008

Project Title: Antithrombin III Targeting to Heparin and HSPG Coated Surfaces. (Co-I)

• Funding Source: NIH R21 HL80610
• Project Date: 4/1/2005 - 3/31/2007

Project Title: Trial to Assess the Effect of High Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemia Subjects with Asymptomatic Carotid Stenosis After 24 Months of Dosing

• Co-Investigator: Mark Sarfati
• Funding Source: AstraZeneca
• Project Date:08/2001-12/2004

Project Title: Control of endothelial translation by fluid shear stress

• Funding Source: Lifeline Foundation®/NHLBI Jointly Sponsored Mentored Clinical Scientist Development Award (K08)
• Project Date: 7/1/1999 - 6/30/2005

Project Title: Specimen-based accuracy of carotid stenosis. NIH multicenter study via contract

• Coordinating Institution: University of California San Francisco, David Saloner (PI)
• Funding Source: RO1 HE 56307
• Project Date:10/1/1999 - 9/30/2000

Project Title: The role of pp70S6k in the biology of endothelial cells

• Funding Source: Wylie Scholar in Academic Vascular Surgery Award. Pacific Vascular Research Foundation
• Project Date: 7/1/1997 - 6/30/2000

Project Title: Fluid shear stress regulation of NF-?B and atherogenesis

• Funding Source: The Lifeline Foundation Faculty Research Award
• Project Date: 7/1/1997 - 6/30/1999

Project Title: Effect of fluid shear stress on PDGF- and NO-mediated interactions between endothelial and smooth muscle cells

• Funding Source: Beginning Grant-in-Aid #9606235S, American Heart Association-Utah Affiliate
• Project Date: 7/1/1996 - 6/30/1997